Endometriosis Can Cause Pain All Month Long

Please refer back to my previous post about Endometriosis and Estrogen for more details on that topic.

Endometriosis is so different from the uterine lining, that it doesn’t always correspond to the usual hormonal changes that induce menstruation. Our hormones fluctuate throughout our cycle, causing specific reactions within the uterus that eventually lead to its shedding, but Endometriosis does not follow the same pattern.

Endometriosis lesions can inflame at any point of the menstrual cycle and also utilize their own Estrogen to inflame and ultimately cause pain and damage.
The uterine lining knows how to respond to hormone changes because of hormone receptors. These receptors are not the same in Endometriosis lesions, which is why they don’t react the same way.

This is important because once again, this is an integral reason why hormonal suppression does not with help pain many individuals with Endometriosis.
To make it even more complex, each of us has different lesions with different hormone receptors – this is possibly why hormone suppression helps with some people’s pain, but not others. It may depend on the individual qualities of your lesions.

Sources:

Laganà AS, Garzon S, Götte M, et al. The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights. Int J Mol Sci. 2019;20(22):5615. Published 2019 Nov 10. doi:10.3390/ijms20225615

David B Redwine,
Was Sampson wrong?,
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Volume 78, Issue 4, 2002

Pietro G. Signorile, Alfonso Baldi,
Endometriosis: New concepts in the pathogenesis, The International Journal of Biochemistry & Cell Biology, Volume 42, Issue 6, 2010

Pietro G. Signorile, Feliciano Baldi, Rossana Bussani, Mariarosaria D’Armiento, Maria De Falco, Mariarosaria Boccellino, Lucio Quagliuolo, Alfonso Baldi, New evidence of the presence of endometriosis in the human fetus,
Reproductive BioMedicine Online,
Volume 21, Issue 1, 2010